Search on: CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 3 
Descriptor Spanish:   Fosfodiesterasas de Nucleótidos Cíclicos Tipo 3 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 3 
Tree Number:   D08.811.277.352.640.150.300
D12.644.360.008.300
D12.776.476.008.300
Definition English:   A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. 
History Note English:   2008(1995) 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   52678 
Unique Identifier:   D054684 

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